The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous estimation of bromhexine HCl (BHX) and phenylephrine HCl (PLE) in their combined pharmaceutical dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point and other being the λmax of one of the two components. BHX and PLE show an isoabsorptive point at 266 nm (λ1). The second wavelength used is 250 nm (λ2), which is the λmax of BHX in methanol. The linearity was obtained in the concentration range of 5-30 μg/ml for BHX and 10-60 μg/ml for PLE. The concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λmax of BHX. The developed method was successfully applied to pharmaceutical dosage form. The results were found to be within acceptance criteria according to ICH guideline.
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